Overview:Systemic Radiotherapy with Monoclonal Antibodies: Options and Problems - Recent Results in Cancer Research 141 - Almost a century ago Paul Ehrlich introduced the "magic bullet" concept of targeting therapeutic agents to specific tissues in order to reduce systemic toxicity. Due to the advances in hybridoma technology in the 1980s, monoclonal antibodies (MAbs) with their exquisite affinity to tumor antigens have become powerful tools in the treatment of cancer, especially when linked to therapeutic agents such as radionuclides, drugs, toxins, or enzymes. It can now be expected that such agents will lead to new cancer treatments with high therapeutic success rates. However, there are major problems in developing this therapeutic concept to a routine treatment modality. This is partly due to factors such as heterogenous distribution of tumor antigens, insufficient blood supply of tumors, high interstitial pressure, and the large interstitial space that antibodies have to traverse. This book is focused on the development in radio immunotherapy (RIT) using radiolabeled monoclonal antibodies as tumoritoxic agents. This area of research has attracted the interest of clinicians and scientists from many different disciplines. It is now clear that the full potential of RIT can only be realized through the concerted efforts of laboratory scientists (molecular biologists, cell physiologists, chemists, radiation physicists, and biologists) and cancer clinicians in nuclear medicine, radiooncology, and internal oncology.

This book is on page /d6967fe9748d6dc60a6682f497bcfd1c/book/1603729754-9783642799549. It was written by the following authors: Marie-Luise Sautter-Bihl, Michael Wannenmacher, Heiner Bihl. Book Systemic Radiotherapy with Monoclonal Antibodies: Options and Problems - Recent Results in Cancer Research 141, which can be read online, published by the company: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG. Other books on similar topics can be found in sections: Science, Medicine, Technology. The book was published on 2011-12-14 00:00:00. It has 198 pages and is published in Paperback format and weight 330 g. File for download Systemic Radiotherapy with Monoclonal Antibodies: Options and Problems - Recent Results in Cancer Research 141 has PDF format and is called systemic-radiotherapy-with-monoclonal-antibodies-options-and-problems-recent-results-in-cancer-research-141.pdf. Other books you can download below. Our sittindonesia.org site is not responsible for the content of PDF files.


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